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ExcelsaDescription: The active ingredients in EXCELSA are dimethyl sulfone and dimethyl sulfoxide.

Purpose: Proposed anti-inflammatory analgesic agent.

Indications and usage: EXCELSA has been used to treat the following conditions; athletic injuries, osteoarthritis, rheumatoid arthritis, scleroderma, interstitial cystitis, thermal and radiation burns, fibromyalgia, lupus and more.

How supplied: Dietary supplement or topical gel. EXCELSA is a product that contains both MSM plus DMSO.

Contraindications: Do not use EXCELSA if you are taking Clinoril, or if you have a known allergy to DMSO. Note: There is no relation between sufla drugs and dietary sulfur as found in EXCELSA.

Interactions/ Reactions:
Oral EXCELSA increases gastrointestinal peristalisis. Secondary to this, mild gastro-intestinal disturbance or an increased frequency of stool may develop. DMSO may potentiate concomitantly administered drugs. Check with your physician prior to use. Occasionally there is an allergic reaction to DMSO (discontinue use). DMSO will carry with it other chemicals with a molecular weight of less than 1000 but will not transport bacteria or viruses. EXCELSA is essentially odorless regardless of the route of administration.

Precautions: Insufficient information is available on using EXCELSA during pregnancy and lactation. Avoid use if you are pregnant, think you may become pregnant or are breast feeding.

Clinical pharmacology: Dimethyl sulfoxide (DMSO) is metabolized in man by oxidation to dimethyl sulfone (MSM) or by reduction to dimethyl sulfide (DMS). DMS and MSM are excreted in the urine and feces. DMS is eliminated thru the breath and skin and is responsible for the characteristic odor from patients on DMSO medication. MSM can persist in serum for longer than 2 weeks after a single application of DMSO. No residual accumulation of DMSO has occurred in man or lower animals who have received DMSO treatment for protracted periods of time. Following oral or topical administration, DMSO and MSM are absorbed and generally distributed in the tissues and body fluids.

Overdosage: MSM is rated as one of the least toxic substances in biology. The lethal dose (LD-50) in mice is over 20gm/kg. When given to human volunteers, no toxic effects were observed at intake levels up to one gm/kg of body weight per day for 30 days. The oral lethal dose (LD50) of DMSO is estimated to be greater than 10 gm/kg. It is improbable that this dosage level could be obtained under normal use.

Administration: Oral EXCELSA is taken by mouth 2 times daily with meals. Topical EXCELSA is applied to the skin 2 to 4 times daily.

Physical charcteristics:
EXCELSA is a clear, colorless, essentially odorless liquid at room temperature.
 



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